Clear Liquids, Safer Procedures—Lessons From the OCULUS Trial - Takeaways - MDSpire
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Transparent Fluids and Enhanced Safety in Procedures: Insights from the OCULUS Study

  • By

  • Venkatesan Thiruvenkatarajan

  • Krishnaswamy Sundararajan

  • Prathicksha Venkatesan

  • September 1, 2026

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  • 1

    The OCULUS trial is the first randomized clinical trial examining GLP-1 and GIP receptor agonists before upper endoscopy.

  • 2

    Procedural safety was enhanced by real-time gastric visualization and predefined decision pathways during the endoscopy.

  • 3

    Participants on a clear liquid diet before the procedure showed no clinically significant residual gastric volume, regardless of medication management.

  • 4

    The trial's findings suggest that stopping medication alone may not fully mitigate periprocedural aspiration risk.

  • 5

    The OCULUS trial supports the implementation of a clear liquid diet as a low-risk measure to reduce residual gastric contents.

Original Source(s)

Clear Liquids, Safer Procedures—Lessons From the OCULUS Trial

  • by Venkatesan Thiruvenkatarajan, Krishnaswamy Sundararajan, Prathicksha Venkatesan

  • September 1, 2026

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