The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study - Takeaways - MDSpire

The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study

  • By

  • Ke-jun Cao

  • Jia-qi Ge

  • Hong-zhi Fang

  • July 6, 2026

  • 0 min

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  • 1

    The VAS score integrates age and vasopressor use into the SIC score to enhance prediction of new-onset MODS in sepsis patients.

  • 2

    In a study of 495 adult sepsis patients, new-onset MODS occurred in 29.9% of cases, highlighting the severity of the condition.

  • 3

    The VAS score demonstrated an AUC of 0.777, outperforming the SIC and qSOFA scores in predicting MODS.

  • 4

    A VAS score of ≥ 4 showed 76.4% sensitivity and 73.2% specificity for predicting MODS, remaining significant after multivariable adjustment.

  • 5

    Dynamic increases in VAS over 48 hours were associated with a 4.78-fold higher risk of MODS, emphasizing the score's prognostic value.

Original Source(s)

The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study

  • by Ke-jun Cao, Jia-qi Ge, Hong-zhi Fang

  • July 6, 2026

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