Prolonged Clinical Results and Recurrence Determinants in Intracranial Germinoma

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Intracranial germinoma is a rare CNS tumor with a higher incidence in East Asia, particularly Japan, compared to Western countries.
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Germinomas have excellent long-term survival rates, with 30-year overall survival rates ranging from 61.9% to 100% based on treatment.
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Recurrence remains a significant concern, with 5- and 10-year progression-free survival rates between 74% and 91%.
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Whole ventricular irradiation is the current standard treatment, as focal radiation increases the risk of distant relapses.
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This study analyzed long-term outcomes and recurrence patterns in 56 patients treated at Kobe University over four decades.

Journal Of Neuro-Oncology

by Masashi Higashino, Kazuhiro Tanaka, Takeaki Ishihara, Hiroaki Nagashima, Yuichi Fujita, Yosuke Fujimoto, Masaaki Kohta, Yoichi Uozumi, Hidehito Kimura, Ryohei Sasaki, Takashi Sasayama
June 4, 2026

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