Impact of Neutropenia on the Effectiveness of Artemisinin-Based Combination Therapy in Pregnant Women in Mali - Takeaways - MDSpire

Impact of Neutropenia on the Effectiveness of Artemisinin-Based Combination Therapy in Pregnant Women in Mali

  • By

  • Moussa Djimde

  • Charles Arama

  • Hamadoun Diakité

  • Mohamed Keita

  • Bouréma Koné

  • Bréhima Tembely

  • Mamadou D. Samaké

  • Balla Bagayoko

  • Mohamed B. Traoré

  • Japhet Kabalu Tshiongo

  • Noluthando Ntlapo

  • Alassane Dicko

  • Michel Vaillant

  • Petra F. Mens

  • Henk D. F. H. Schallig

  • Kassoum Kayentao

  • January 27, 2026

  • 0 min

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  • 1

    Malaria during pregnancy significantly increases maternal and infant mortality rates, particularly in Mali, where the maternal mortality rate is 562 per 100,000 live births.

  • 2

    Neutrophils are crucial for the immune response against malaria, but their role in the efficacy of artemisinin-based combination therapies (ACTs) in pregnant women is not well understood.

  • 3

    The study investigates the impact of neutropenia on the effectiveness of three ACTs: artemether-lumefantrine, dihydroartemisinin-piperaquine, and pyronaridine-artesunate.

  • 4

    Conducted in Mali, the study involved pregnant women with confirmed Plasmodium falciparum infection, assessing neutrophil dynamics during a 63-day follow-up.

  • 5

    Findings from this research could provide insights into the relationship between neutrophil levels and the efficacy of malaria treatments in pregnant women.

Original Source(s)

Impact of Neutropenia on the Effectiveness of Artemisinin-Based Combination Therapy in Pregnant Women in Mali

  • by Moussa Djimde, Charles Arama, Hamadoun Diakité, Mohamed Keita, Bouréma Koné, Bréhima Tembely, Mamadou D. Samaké, Balla Bagayoko, Mohamed B. Traoré, Japhet Kabalu Tshiongo, Noluthando Ntlapo, Alassane Dicko, Michel Vaillant, Petra F. Mens, Henk D. F. H. Schallig, Kassoum Kayentao

  • January 27, 2026

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