HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis - Takeaways - MDSpire

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis

  • By

  • Dongling Li

  • Qinrui Cai

  • Ling Lin

  • Li Li

  • Yao Chen

  • Tianlin Feng

  • Xiaoya Zhou

  • Jia Xie

  • Xiaohong Fu

  • Chuanwei Li

  • Jun Xiao

  • Fan Yang

  • June 16, 2026

  • 0 min

Share

  • 1

    Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths globally.

  • 2

    Global crotonylation levels were significantly higher in colorectal tumor specimens compared to adjacent normal tissues.

  • 3

    Decrotonylation of CDK1 at K9 inhibited CRC cell proliferation and migration by arresting the cell cycle and inducing apoptosis.

  • 4

    Histone acetyltransferase hMOF and histone deacetylase HDAC1 co-mediated CDK1 K9 crotonylation, affecting its kinase activity.

  • 5

    CDK1 K9 decrotonylation enhances the efficacy of CDK1 inhibitors, demonstrating a synergistic effect in CRC treatment.

Original Source(s)

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis

  • by Dongling Li, Qinrui Cai, Ling Lin, Li Li, Yao Chen, Tianlin Feng, Xiaoya Zhou, Jia Xie, Xiaohong Fu, Chuanwei Li, Jun Xiao, Fan Yang

  • June 16, 2026

Related Content

The role of NAD+ metabolic reprogramming in colorectal cancer chemoresistance: mechanistic insights, clinical translation challenges and opportunities

Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis

The longstanding issue of the benefit of ursodeoxycholic acid in primary sclerosing cholangitis: a long-term population-based study