Bone health in neuroendocrine tumors and prognostic implications beyond skeletal metastases

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The study assessed musculoskeletal health in 41 patients with gastroenteropancreatic and lung neuroendocrine tumors.
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Seventy-one percent of NET patients exhibited degraded trabecular bone scores, with 59% showing osteopenia at the femoral neck.
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Advanced-stage NETs correlated with significantly lower bone mineral density and vitamin D levels compared to earlier-stage disease.
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Higher vitamin D levels and BMI were independently associated with longer progression-free survival in NET patients.
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NET patients had significantly lower trabecular bone scores compared to healthy controls, indicating substantial musculoskeletal impairment.

Frontiers In Endocrinology

by Andrea Casabella, Iderina Hasballa, Anna Arecco, Mara Boschetti, Leonardo Della Sala, Davide Demontis, Alberto Sulli, Lara Vera, Alessandro Veresani, Diego Ferone, Sabrina Paolino, Manuela Albertelli
July 1, 2026

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