SF3B4 stabilizes SREBF1 via 3′UTR binding to drive hepatocellular carcinoma progression - Takeaways - MDSpire

SF3B4 stabilizes SREBF1 via 3′UTR binding to drive hepatocellular carcinoma progression

  • By

  • Yuan Fang

  • Dan Wang

  • Lei Han

  • Mengge Li

  • Qiuyue He

  • WangGan Xu

  • HaiJing Li

  • Zhong Zeng

  • Jie Lin

  • HanFei Huang

  • May 21, 2026

  • 0 min

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  • 1

    SF3B4 is significantly elevated in hepatocellular carcinoma (HCC) tissues and correlates with poor overall survival and disease-free survival.

  • 2

    SF3B4 enhances the stability and expression of SREBF1 mRNA by directly binding to its 3′ untranslated region.

  • 3

    SREBF1 promotes HCC cell proliferation, invasion, and migration while inhibiting apoptosis, indicating its role in tumor progression.

  • 4

    Silencing SF3B4 in xenograft models significantly inhibits tumor growth and reduces SREBF1 expression.

  • 5

    The SF3B4-SREBF1 axis connects RNA metabolism dysregulation to lipid metabolic reprogramming, presenting new therapeutic targets for HCC.

Original Source(s)

SF3B4 stabilizes SREBF1 via 3′UTR binding to drive hepatocellular carcinoma progression

  • by Yuan Fang, Dan Wang, Lei Han, Mengge Li, Qiuyue He, WangGan Xu, HaiJing Li, Zhong Zeng, Jie Lin, HanFei Huang

  • May 21, 2026

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