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1
A 71-year-old man presented with symptoms including fever, splenomegaly, and cytopenia, leading to a diagnosis of stage IVB diffuse large B-cell lymphoma.
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2
After initial chemotherapy, the patient experienced persistent thrombocytopenia and splenomegaly, prompting a splenectomy for suspected hypersplenism.
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3
Splenectomy revealed peripheral T-cell lymphoma, indicating a lineage-discordant lymphoma coexisting with the previously diagnosed B-cell lymphoma.
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4
The case highlights the importance of repeat tissue sampling and reassessment in patients with persistent splenomegaly and cytopenia during lymphoma treatment.
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5
The patient ultimately experienced multiple relapses and died 33 months after initial presentation, underscoring the complexity of coexisting lymphomas.
