Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank - Takeaways - MDSpire

Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank

  • By

  • Ye Ding

  • Jie Wang

  • Nan Wang

  • Jinyu Zhu

  • Xiaoxiao Wang

  • Peibei Duan

  • July 10, 2026

  • 0 min

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  • 1

    The study analyzed data from 385,206 UK Biobank participants to evaluate non-insulin surrogate markers for insulin resistance and colorectal cancer risk.

  • 2

    Four surrogate markers were assessed: TyG index, TyG-BMI, TG/HDL-C ratio, and METS-IR, all showing positive associations with colorectal cancer risk.

  • 3

    Over a median follow-up of 13.8 years, 5,175 incident colorectal cancer cases were documented, with hazard ratios indicating increased risk.

  • 4

    METS-IR and TyG-BMI provided the most significant improvements in risk stratification, as indicated by C-index increments.

  • 5

    Subgroup analyses revealed significant interactions between insulin resistance markers and factors like age, sex, and smoking status.

Original Source(s)

Association of four non-insulin-based insulin resistance surrogate markers with colorectal cancer risk: a large-scale prospective cohort study using the UK Biobank

  • by Ye Ding, Jie Wang, Nan Wang, Jinyu Zhu, Xiaoxiao Wang, Peibei Duan

  • July 10, 2026

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