Efficacy and safety of hyperthermic intraperitoneal chemotherapy in treatment of primary or recurrent ovarian cancer: systematic review and meta-analysis - Takeaways - MDSpire

Efficacy and safety of hyperthermic intraperitoneal chemotherapy in treatment of primary or recurrent ovarian cancer: systematic review and meta-analysis

  • By

  • Abdullah Ali Al Ameer

  • Shahad Essa Alrehaili

  • Doaa Wahib Nabulsy

  • Fatimah Osama Alhamdan

  • Lina Saleh Aljedani

  • Dareen Khalid Abdulshafi

  • Bedoor Obidallah Alghanmi

  • Abdulrahman Saleh Al-Mulhim

  • June 11, 2026

  • 0 min

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  • 1

    HIPEC may improve overall survival in patients with primary advanced ovarian cancer when combined with standard multimodal treatment.

  • 2

    The meta-analysis included six randomized controlled trials with a total of 773 patients, providing moderate-quality evidence.

  • 3

    No significant survival benefit was observed for HIPEC in patients with recurrent ovarian cancer.

  • 4

    Postoperative complications did not significantly differ between patients receiving HIPEC and those who did not.

  • 5

    The findings suggest cautious interpretation of HIPEC's role in ovarian cancer treatment due to limited and heterogeneous evidence.

Original Source(s)

Efficacy and safety of hyperthermic intraperitoneal chemotherapy in treatment of primary or recurrent ovarian cancer: systematic review and meta-analysis

  • by Abdullah Ali Al Ameer, Shahad Essa Alrehaili, Doaa Wahib Nabulsy, Fatimah Osama Alhamdan, Lina Saleh Aljedani, Dareen Khalid Abdulshafi, Bedoor Obidallah Alghanmi, Abdulrahman Saleh Al-Mulhim

  • June 11, 2026

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