Reproducible Molecular Subtypes in Systemic Lupus Erythematosus Are Associated With Disease Activity, Serology, and Distinct Trajectories Over Time - Takeaways - MDSpire

Consistent Molecular Subtypes in Systemic Lupus Erythematosus Correlate With Disease Activity, Serological Profiles, and Unique Longitudinal Patterns

  • By

  • Loqmane Seridi

  • Eugene Myshkin

  • Erika Noss

  • Sheng Gao

  • Julio Molineros

  • Carolyn Cuff

  • Dawn Waterworth

  • Matthew J. Loza

  • July 1, 2026

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  • 1

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by heterogeneous manifestations across organ systems.

  • 2

    Whole-blood transcriptomic studies have identified immune programs in SLE, including elevated interferon signaling and B cell/plasmablast activation.

  • 3

    The study utilized three large SLE cohorts to identify robust molecular subtypes and assess their reproducibility across platforms and sample types.

  • 4

    Consensus clustering identified six distinct molecular subtypes in the ILLUMINATE cohort, which were validated in LOTUS and Genuity Science cohorts.

  • 5

    Serum proteomics and transcriptomics were integrated to characterize each subtype based on clinical features, serology, and longitudinal stability.

Original Source(s)

Reproducible Molecular Subtypes in Systemic Lupus Erythematosus Are Associated With Disease Activity, Serology, and Distinct Trajectories Over Time

  • by Loqmane Seridi, Eugene Myshkin, Erika Noss, Sheng Gao, Julio Molineros, Carolyn Cuff, Dawn Waterworth, Matthew J. Loza

  • July 1, 2026

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