Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates - Takeaways - MDSpire

Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates

  • By

  • Nina M Frerichs

  • Nancy Deianova

  • Sofia el Manouni el Hassani

  • Animesh Acharjee

  • Mohammed Nabil Quraishi

  • Willem P de Boode

  • Veerle Cossey

  • Christian V Hulzebos

  • Anton H van Kaam

  • Boris W Kramer

  • Esther d’Haens

  • Wouter J de Jonge

  • Daniel C Vijlbrief

  • Mirjam M van Weissenbruch

  • Emma Daulton

  • Alfian N Wicaksono

  • James A Covington

  • Marc A Benninga

  • Nanne K H de Boer

  • Johannes B van Goudoever

  • Hendrik J Niemarkt

  • Tim G J de Meij

  • May 23, 2024

  • 0 min

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  • 1

    Fecal microbiota and volatile metabolome changes may precede late-onset meningitis (LOM) in preterm infants.

  • 2

    The study analyzed fecal samples from 1397 preterm infants, identifying 21 cases of LOM and 19 cases of concomitant late-onset sepsis.

  • 3

    A random forest model based on microbiota features predicted LOM with an area under the curve (AUC) of 0.88, indicating strong predictive capability.

  • 4

    Volatile metabolome analysis showed moderate association with preclinical LOM, with AUC values ranging from 0.70 to 0.76.

  • 5

    The findings suggest that microbiota composition alterations could serve as noninvasive biomarkers for early LOM diagnosis in preterm infants.

Original Source(s)

Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates

  • by Nina M Frerichs, Nancy Deianova, Sofia el Manouni el Hassani, Animesh Acharjee, Mohammed Nabil Quraishi, Willem P de Boode, Veerle Cossey, Christian V Hulzebos, Anton H van Kaam, Boris W Kramer, Esther d’Haens, Wouter J de Jonge, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Emma Daulton, Alfian N Wicaksono, James A Covington, Marc A Benninga, Nanne K H de Boer, Johannes B van Goudoever, Hendrik J Niemarkt, Tim G J de Meij

  • May 23, 2024

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