Successful management of severe Pneumocystis jirovecii pneumonia with inhaled nitric oxide and individualized ventilatory strategies in an immunosuppressed patient: a case report - Takeaways - MDSpire

Successful management of severe Pneumocystis jirovecii pneumonia with inhaled nitric oxide and individualized ventilatory strategies in an immunosuppressed patient: a case report

  • By

  • Haobo Kong

  • Jingjing Pan

  • Jialin Liu

  • Min Liang

  • Liu Liu

  • Hua Niu

  • Ye Li

  • May 22, 2026

  • 0 min

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  • 1

    A 69-year-old HIV-negative man with extensive-stage SCLC developed severe Pneumocystis jirovecii pneumonia after receiving immune checkpoint inhibitors.

  • 2

    Metagenomic next-generation sequencing identified P. jirovecii as the predominant pathogen in a mixed pulmonary infection.

  • 3

    The patient was treated with trimethoprim-sulfamethoxazole, cefoperazone-sulbactam, and caspofungin for the mixed infection.

  • 4

    Comprehensive respiratory support, including inhaled nitric oxide and tailored mechanical ventilation, improved the patient's oxygenation.

  • 5

    The case highlights the importance of early diagnosis and targeted therapy for severe PJP in immunocompromised patients.

Original Source(s)

Successful management of severe Pneumocystis jirovecii pneumonia with inhaled nitric oxide and individualized ventilatory strategies in an immunosuppressed patient: a case report

  • by Haobo Kong, Jingjing Pan, Jialin Liu, Min Liang, Liu Liu, Hua Niu, Ye Li

  • May 22, 2026

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