PANoptosis in diabetic retinopathy: immunological insights into mechanisms and translational therapies - Takeaways - MDSpire
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Understanding PANoptosis in Diabetic Retinopathy: Immunological Mechanisms and Potential Therapeutic Approaches

  • By

  • Lingli Ma

  • Ning Hou

  • Xiaoyu Zhao

  • Zimeng Li

  • Qing Liu

  • Jianyu Zhao

  • Qing Wang

  • June 19, 2026

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  • 1

    Diabetic retinopathy (DR) is a major cause of blindness, driven by hyperglycemia-induced neurovascular damage and characterized by retinal neurodegeneration.

  • 2

    PANoptosis, an inflammatory programmed cell death modality, plays a role in the progression of diabetic retinal damage.

  • 3

    Research on PANoptosis in DR highlights gaps in understanding its mechanisms, including PANoptosome signaling and the role of non-coding RNAs.

  • 4

    Current therapeutic strategies should prioritize biomarker-guided, localized delivery and cell-type-specific modulation of PANoptosis-related pathways.

  • 5

    The review emphasizes the need for mechanistic verification and well-designed clinical trials to advance targeted interventions in DR.

Original Source(s)

PANoptosis in diabetic retinopathy: immunological insights into mechanisms and translational therapies

  • by Lingli Ma, Ning Hou, Xiaoyu Zhao, Zimeng Li, Qing Liu, Jianyu Zhao, Qing Wang

  • June 19, 2026

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