Distribution and molecular drivers of the 21-gene recurrence score in early breast cancer with low, intermediate, and high estrogen receptor expression - Takeaways - MDSpire

Distribution and molecular drivers of the 21-gene recurrence score in early breast cancer with low, intermediate, and high estrogen receptor expression

  • By

  • Shuai Li

  • Jiahui Huang

  • Yifei Zhu

  • Jin Hong

  • Siji Zhu

  • Weiqi Gao

  • Ou Huang

  • Jianrong He

  • Weiguo Chen

  • Yafen Li

  • Xiaosong Chen

  • Kunwei Shen

  • Jiayi Wu

  • April 30, 2026

  • 0 min

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  • 1

    The study analyzed the 21-gene recurrence score (RS) in early-stage breast cancer with varying estrogen receptor (ER) expression levels.

  • 2

    A total of 4754 patients were categorized into ER-low, ER-intermediate, and ER-high groups, with mean RS values of 39, 32, and 24, respectively.

  • 3

    Higher RS values were observed in ER-low patients, particularly among those aged ≤50 years and with high clinical risk or PR-negative diseases.

  • 4

    The expression of key genes was significantly lower in ER-low tumors compared to ER-high tumors, indicating distinct molecular profiles.

  • 5

    The findings suggest that the 21-gene RS has limited predictive value in ER-low tumors, necessitating further validation in larger cohorts.

Original Source(s)

Distribution and molecular drivers of the 21-gene recurrence score in early breast cancer with low, intermediate, and high estrogen receptor expression

  • by Shuai Li, Jiahui Huang, Yifei Zhu, Jin Hong, Siji Zhu, Weiqi Gao, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen, Jiayi Wu

  • April 30, 2026

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