Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China - Takeaways - MDSpire

Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China

  • By

  • Jingjuan Chen

  • Wenyuan Liu

  • Yibo Chen

  • Wenbo Lu

  • Yunlong Liu

  • Yefang Ke

  • July 17, 2026

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  • 1

    The study analyzed 1,981 pediatric appendectomy cases in Ningbo, China, from 2019 to 2024, focusing on bacterial pathogens and resistance patterns.

  • 2

    Escherichia coli was the most common pathogen, found in 55.12% of positive cultures, followed by Pseudomonas aeruginosa and Comamonas testosteroni.

  • 3

    E. coli exhibited high resistance rates to ampicillin (84.56%) and trimethoprim-sulfamethoxazole (55.67%), while resistance to piperacillin/tazobactam was low.

  • 4

    Polymicrobial infections were more prevalent in gangrenous appendicitis (42.07%) compared to non-gangrenous cases (33.70%).

  • 5

    The study suggests that reliance on third-generation cephalosporins for treatment may be insufficient due to significant E. coli resistance.

Original Source(s)

Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China

  • by Jingjuan Chen, Wenyuan Liu, Yibo Chen, Wenbo Lu, Yunlong Liu, Yefang Ke

  • July 17, 2026

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