Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025 - Takeaways - MDSpire
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Mortality Trends and Inequities Related to Atherosclerotic Cardiovascular Disease and Stroke Among Adults in the U.S., 1999–2025

  • By

  • Muhammad Atif Mazhar

  • Abdal Ahmad

  • Vishan Das

  • Danyal Ahmad

  • Kaneez Fatima

  • Muhammad Mukhlis

  • Eshal Atif

  • Zubair Ahmed

  • Sadia Qazi

  • July 16, 2026

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  • 1

    A total of 876,383 deaths involving coexisting ASCVD- and stroke-related conditions were identified from 1999 to 2025.

  • 2

    The overall average age-adjusted mortality rate declined from 26.82 per 100,000 in 1999 to 10.91 per 100,000 in 2025.

  • 3

    Mortality rates showed a borderline significant increase during 2018-2021, followed by a renewed decline from 2021 to 2025.

  • 4

    Disparities in mortality rates persisted, with higher burdens among men, older adults, Black individuals, and non-metropolitan populations.

  • 5

    Adults aged 25-44 years experienced a significant increase in mortality rates after 2015, although absolute rates remained low.

Original Source(s)

Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025

  • by Muhammad Atif Mazhar, Abdal Ahmad, Vishan Das, Danyal Ahmad, Kaneez Fatima, Muhammad Mukhlis, Eshal Atif, Zubair Ahmed, Sadia Qazi

  • July 16, 2026

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