Association between perfluoroalkyl and polyfluoroalkyl substances and response to the COVID-19 vaccine in a paediatric prospective observational cohort in Arizona - Takeaways - MDSpire

Association between perfluoroalkyl and polyfluoroalkyl substances and response to the COVID-19 vaccine in a paediatric prospective observational cohort in Arizona

  • By

  • James Hollister

  • Cynthia Porter

  • Boqi Xiang

  • Shawn C Beitel

  • Patrick Rivers

  • Karen Lutrick

  • Jefferey L Burgess

  • Katherine D Ellingson

  • June 22, 2026

  • 0 min

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  • 1

    The study investigates the relationship between PFAS exposure and COVID-19 vaccine efficacy in children aged 6 months to 17 years.

  • 2

    Increased serum PFOS concentration was significantly associated with a 5.0% decrease in antibody response to the COVID-19 vaccine.

  • 3

    The study included 120 participants who received the Pfizer-BioNTech COVID-19 vaccine and had no prior SARS-CoV-2 infection.

  • 4

    Regression models adjusted for age, sex, geographic region, and chronic conditions were used to analyze the data.

  • 5

    This research adds to evidence suggesting PFAS exposure negatively impacts immune response to vaccinations in children.

Original Source(s)

Association between perfluoroalkyl and polyfluoroalkyl substances and response to the COVID-19 vaccine in a paediatric prospective observational cohort in Arizona

  • by James Hollister, Cynthia Porter, Boqi Xiang, Shawn C Beitel, Patrick Rivers, Karen Lutrick, Jefferey L Burgess, Katherine D Ellingson

  • June 22, 2026

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