Dupilumab Faces Trial in Chronic Hives

Phase III CUPID-C trial evaluates biologic therapy in patients with chronic spontaneous urticaria uncontrolled by antihistamines.

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Dupilumab significantly reduced itch severity and urticaria activity in chronic spontaneous urticaria patients unresponsive to antihistamines.
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The LIBERTY-CSU CUPID-C trial involved 151 patients aged 6 to 80 years, demonstrating dupilumab's efficacy over a 24-week period.
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At week 24, 70% of dupilumab patients achieved a 5-point reduction in itch severity, compared to 52% in the placebo group.
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Safety profiles were similar between dupilumab and placebo, with common adverse events including nasopharyngitis and injection-site reactions.
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The study confirmed dupilumab's benefits for patients with CSU, reinforcing its clinical efficacy and safety for those resistant to standard treatments.

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