Rural-Urban Disparities in Hepatocellular Carcinoma Incidence and Mortality - Takeaways - MDSpire

Rural-Urban Disparities in Hepatocellular Carcinoma Incidence and Mortality

  • By

  • Haluk Damgacioglu

  • Gokhan Uygun

  • Ashish A. Deshmukh

  • Ahmed O. Kaseb

  • Anne M. Noonan

  • Tarik Demir

  • May 13, 2026

  • 0 min

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  • 1

    Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, with major risk factors including chronic viral hepatitis and metabolic dysfunction.

  • 2

    Rural populations exhibit higher prevalence of HCC risk factors, raising concerns about geographic disparities in HCC incidence and mortality.

  • 3

    From 2001 to 2022, HCC incidence among men increased in rural areas while decreasing in urban areas, highlighting significant rural-urban disparities.

  • 4

    Women in rural counties showed a steady increase in HCC incidence, contrasting with urban women who experienced fluctuating trends.

  • 5

    The study utilized NPCR and SEER databases to analyze HCC trends by sex, race, ethnicity, and stage at diagnosis from 2001 to 2022.

Original Source(s)

Rural-Urban Disparities in Hepatocellular Carcinoma Incidence and Mortality

  • by Haluk Damgacioglu, Gokhan Uygun, Ashish A. Deshmukh, Ahmed O. Kaseb, Anne M. Noonan, Tarik Demir

  • May 13, 2026

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