Tumor-associated neutrophils in lung adenocarcinoma: from mechanisms to therapeutic targeting - Takeaways - MDSpire

Neutrophils Associated with Tumors in Lung Adenocarcinoma: Exploring Mechanisms and Potential Therapeutic Approaches

  • By

  • Ruichen Zhang

  • July 20, 2026

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  • 1

    Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC), characterized by a complex tumor microenvironment.

  • 2

    Tumor-associated neutrophils (TANs) in LUAD can exhibit dual functions, promoting or suppressing tumor growth depending on their polarization.

  • 3

    TANs are recruited to tumor sites via the CXCR1/CXCR2 axis, influenced by chemokines secreted by tumor and stromal cells.

  • 4

    Current therapeutic strategies targeting TANs include CXCR1/2 inhibitors, PAD4 inhibitors, and NET-degrading enzymes, supported by preclinical evidence.

  • 5

    Challenges in targeting TANs for therapy include off-target toxicity, infection risk, and the absence of predictive biomarkers.

Original Source(s)

Tumor-associated neutrophils in lung adenocarcinoma: from mechanisms to therapeutic targeting

  • by Ruichen Zhang

  • July 20, 2026

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