Association between early postnatal antibiotic exposure and bronchopulmonary dysplasia in very preterm infants: a meta-analysis - Takeaways - MDSpire

Association between early postnatal antibiotic exposure and bronchopulmonary dysplasia in very preterm infants: a meta-analysis

  • By

  • Cheng Min

  • Ying Sui

  • Qu Chen

  • July 16, 2026

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  • 1

    Early postnatal antibiotic exposure is linked to an increased risk of bronchopulmonary dysplasia (BPD) in very preterm infants.

  • 2

    The meta-analysis included 11 studies and found a pooled odds ratio of 1.44 for BPD associated with early antibiotic exposure.

  • 3

    Increased risks of necrotizing enterocolitis (NEC) and mortality were also observed, with odds ratios of 1.18 and 1.19, respectively.

  • 4

    No significant association was found between early antibiotic exposure and late-onset sepsis in very preterm infants.

  • 5

    The study emphasizes the need for careful assessment of infection risk and optimization of antibiotic use in neonatal care.

Original Source(s)

Association between early postnatal antibiotic exposure and bronchopulmonary dysplasia in very preterm infants: a meta-analysis

  • by Cheng Min, Ying Sui, Qu Chen

  • July 16, 2026

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