Hyperthermia enhances the efficacy of PD-1 inhibitor plus chemotherapy in PD-L1 CPS-negative advanced gastric cancer

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Hyperthermia combined with PD-1 inhibitors and chemotherapy significantly improves progression-free survival in PD-L1 CPS-negative advanced gastric cancer patients.
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The study involved 72 patients, with 37 receiving hyperthermia alongside treatment, showing better outcomes compared to the chemotherapy-only group.
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Patients in the hyperthermia group experienced less fatigue and anorexia, indicating a reduction in certain adverse effects.
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Circulating tumor cell dynamics differed between groups, with the hyperthermia cohort showing a greater increase post-treatment.
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The findings suggest hyperthermia may enhance immune activation and tumor cell eradication, warranting further investigation into its mechanisms.

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