Fracture Risk Associated With Long-Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population-Based Study Using National Claims Data (Système National des Données de Santé) - Takeaways - MDSpire
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Long-Term Cessation of Osteoporosis Therapy in Postmenopausal Women and Its Impact on Fracture Risk: Insights from a French National Claims Data Analysis

  • By

  • Audrey Lajoinie

  • Meriem Benmerad

  • Magali Laborey

  • Pascale Samama

  • Gaëlle Désaméricq

  • Leila Chelbani

  • Karine Briot

  • September 1, 2026

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  • 1

    Osteoporosis affects over 200 million people globally, leading to approximately 8.9 million fragility fractures annually.

  • 2

    In France, around 4 million individuals had osteoporosis in 2019, resulting in an estimated 1,325 fractures daily.

  • 3

    Bisphosphonates are recommended for initial treatment of postmenopausal osteoporosis, while denosumab is a second-line therapy.

  • 4

    Long-term discontinuation of bisphosphonate therapy may be considered for patients with low fracture risk after three to five years.

  • 5

    The study utilized French national claims data to assess the incidence of long-term discontinuation and its impact on fracture risk.

Original Source(s)

Fracture Risk Associated With Long-Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population-Based Study Using National Claims Data (Système National des Données de Santé)

  • by Audrey Lajoinie, Meriem Benmerad, Magali Laborey, Pascale Samama, Gaëlle Désaméricq, Leila Chelbani, Karine Briot

  • September 1, 2026

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