Brain metastasis secondary to primary vaginal clear cell adenocarcinoma not associated with diethylstilbestrol: a case report and a review of the literature - Takeaways - MDSpire
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Brain Metastasis from Primary Vaginal Clear Cell Adenocarcinoma Unrelated to Diethylstilbestrol: A Case Study and Literature Review

  • By

  • Esther Anyimadu Buckson

  • Obi Emereole

  • John Richard Ouma

  • September 3, 2026

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  • 1

    Primary clear cell adenocarcinoma of the vagina (PCCAV) accounts for 5%-10% of primary vaginal cancers and is linked to poorer prognosis when non-DES-related.

  • 2

    A 17-year-old female presented with cerebral metastases from non-DES-related PCCAV, experiencing left-sided weakness and seizures.

  • 3

    CT imaging revealed a right parietal mass and pulmonary metastases, confirming the diagnosis of metastatic clear cell vaginal adenocarcinoma.

  • 4

    The patient underwent emergent gross total excision of the brain lesion, but her prognosis remained poor, leading to palliative care.

  • 5

    This case highlights the lack of established management guidelines for metastatic PCCAV and the need for further research in this area.

Original Source(s)

Brain metastasis secondary to primary vaginal clear cell adenocarcinoma not associated with diethylstilbestrol: a case report and a review of the literature

  • by Esther Anyimadu Buckson, Obi Emereole, John Richard Ouma

  • September 3, 2026

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