Biological Heterogeneity in Susceptibility to Glucocorticoid-Induced Bone Loss: Short- and Long-Term Hip BMD Trajectories

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Glucocorticoids (GCs) negatively impact bone health by decreasing bone formation and increasing fracture risk.
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The study analyzed total hip bone mineral density (THBMD) changes in adults starting systemic GC treatment.
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Significant associations were found between GC exposure and THBMD loss, particularly in higher exposure tertiles.
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Approximately 20% of patients experienced no bone loss despite high levels of GC exposure, indicating variability in responses.
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Early monitoring and personalized management strategies are essential for patients undergoing GC treatment to protect bone health.

The Journal Of Clinical Endocrinology & Metabolism

by Benjamin Bakke Hansen, Katrine Hass Rubin, Catharina Vind Nielsen, Morten Frost Nielsen, Anne Pernille Hermann, Bo Abrahamsen
December 3, 2024

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