Vitamin D: The Answer May Be Genetic

A post hoc D2d analysis found vitamin D3 supplementation was linked to lower diabetes risk only among patients with ApaI AC or CC genotypes.

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Vitamin D3 supplementation reduced diabetes progression by 19% in patients with prediabetes carrying AC or CC genotypes, but not in those with the AA genotype.
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The Vitamin D and Type 2 Diabetes trial was a randomized, double-blind study involving 2,098 participants followed for a median of 2.5 years.
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The study found that higher levels of 25-hydroxyvitamin D were associated with lower diabetes risk in AC and CC genotype carriers.
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Findings suggest that genetic variants in the vitamin D receptor may influence individual responses to vitamin D supplementation.
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The results are exploratory and require further confirmation in future trials, as the study was not powered for subgroup analyses.

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