Exercise modulation of BDNF/TrkB signaling in Parkinson’s disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps - Takeaways - MDSpire

Exercise modulation of BDNF/TrkB signaling in Parkinson’s disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps

  • By

  • Chuan Chen

  • Kaihua Liu

  • Meng Xiang

  • Xueqin Zhang

  • June 25, 2026

  • 0 min

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  • 1

    Parkinson's disease is characterized by dopaminergic neuronal loss and leads to various motor and non-motor impairments.

  • 2

    Exercise is a promising adjunctive strategy for Parkinson's disease, improving functional outcomes and engaging neuroprotective processes.

  • 3

    BDNF and TrkB signaling are crucial for neuronal survival and synaptic plasticity, with exercise potentially influencing these pathways.

  • 4

    Preclinical studies suggest exercise may enhance dopaminergic preservation and activate key signaling pathways related to neuroprotection.

  • 5

    Key translational gaps exist in BDNF biomarker limitations and the need for aligning exercise prescriptions with specific BDNF/TrkB mechanisms.

Original Source(s)

Exercise modulation of BDNF/TrkB signaling in Parkinson’s disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps

  • by Chuan Chen, Kaihua Liu, Meng Xiang, Xueqin Zhang

  • June 25, 2026

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