Urinary antimicrobial peptides and cytokines as biomarkers for recurrent urinary tract infection in children and adolescents - Takeaways - MDSpire

Urinary antimicrobial peptides and cytokines as biomarkers for recurrent urinary tract infection in children and adolescents

  • By

  • Guillermo Yepes

  • Hancong Chloe Tang

  • Natalie Holdsworth

  • Kristin Salamon

  • Laura Schwartz

  • Christina Ching

  • Steve Rust

  • John David Spencer

  • June 15, 2026

  • 0 min

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  • 1

    Recurrent urinary tract infection (rUTI) poses significant diagnostic challenges and affects pediatric patients' quality of life.

  • 2

    Urinary concentrations of antimicrobial peptides and cytokines differ significantly between children with rUTI and healthy controls.

  • 3

    Participants with rUTI exhibited lower levels of certain antimicrobial peptides and higher levels of proinflammatory cytokines.

  • 4

    A multivariable classification model using urinary biomarkers demonstrated high accuracy in identifying rUTI status.

  • 5

    The study highlights the potential of urinary immune profiles as biomarkers for diagnosing and managing recurrent UTIs in youth.

Original Source(s)

Urinary antimicrobial peptides and cytokines as biomarkers for recurrent urinary tract infection in children and adolescents

  • by Guillermo Yepes, Hancong Chloe Tang, Natalie Holdsworth, Kristin Salamon, Laura Schwartz, Christina Ching, Steve Rust, John David Spencer

  • June 15, 2026

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