Paper Diagnostics Meet Cancer Biomarkers
A microfluidic paper platform detects microRNA in spiked serum samples using a simple color-based readout
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A paper-based diagnostic device was developed to rapidly detect miRNA-21, a microRNA linked to cancer.
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The device uses gold-platinum nanoparticles for colorimetric detection, changing color in the presence of miRNA-21.
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It demonstrated a detection range of 1–2000 nmol/L and a limit of 0.25 nmol/L under optimized conditions.
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The device allows for quantification of results using smartphone images and ImageJ software.
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This technology aims to provide faster, lower-cost cancer biomarker testing in resource-limited settings.
