Frailty in HIV linked to inflammation, bone health, T-cell exhaustion - Takeaways - MDSpire
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Frailty in HIV linked to inflammation, bone health, T-cell exhaustion

Osteoprotegerin was the soluble marker most strongly linked to T-cell phenotypes among participants with frailty.

  • By

  • Olivia Anderson

  • September 8, 2026

  • 3 min

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  • 1

    Frailty in individuals with HIV is linked to inflammatory proteins, bone health markers, and T-cell exhaustion.

  • 2

    The study involved 120 participants with HIV, half of whom met frailty criteria based on modified Fried criteria.

  • 3

    Nineteen of 75 plasma markers were significantly associated with frailty, particularly those related to NF-κB signaling.

  • 4

    Participants with frailty exhibited lower naïve CD4 and CD8 T cells and higher PD-1 and TIGIT expression.

  • 5

    Osteoprotegerin was the marker most strongly associated with T-cell phenotypes and frailty among participants.

Original Source(s)

Frailty in HIV linked to inflammation, bone health, T-cell exhaustion

  • by Olivia Anderson

  • September 8, 2026

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