Frailty in HIV linked to inflammation, bone health, T-cell exhaustion

Osteoprotegerin was the soluble marker most strongly linked to T-cell phenotypes among participants with frailty.

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Frailty in individuals with HIV is linked to inflammatory proteins, bone health markers, and T-cell exhaustion.
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The study involved 120 participants with HIV, half of whom met frailty criteria based on modified Fried criteria.
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Nineteen of 75 plasma markers were significantly associated with frailty, particularly those related to NF-κB signaling.
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Participants with frailty exhibited lower naïve CD4 and CD8 T cells and higher PD-1 and TIGIT expression.
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Osteoprotegerin was the marker most strongly associated with T-cell phenotypes and frailty among participants.

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