CTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC - Takeaways - MDSpire

CTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC

  • By

  • Jaimin K. Rana

  • Emile S. Pinarbasi

  • Martin G. Fernandez

  • Vikas Navratna

  • Kyle S. Conway

  • Andrew P. Lieberman

  • Sami J. Barmada

  • Shyamal Mosalaganti

  • July 7, 2026

  • 0 min

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  • 1

    Alzheimer's disease neuropathologic change (ADNC) is characterized by amyloid-β plaques and tau neurofibrillary tangles.

  • 2

    Cryo-electron microscopy revealed two tau filament polymorphs in ADNC: paired helical filament (PHF) and straight filament (SF).

  • 3

    Up to 50% of ADNC patients also have limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC).

  • 4

    In two AD + LATE-NC cases, tau adopted a chronic traumatic encephalopathy (CTE) fold alongside the classical AD-fold.

  • 5

    CTE neuropathologic change (CTE-NC) was identified in one case, despite no history of traumatic head injury or contact sports.

Original Source(s)

CTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC

  • by Jaimin K. Rana, Emile S. Pinarbasi, Martin G. Fernandez, Vikas Navratna, Kyle S. Conway, Andrew P. Lieberman, Sami J. Barmada, Shyamal Mosalaganti

  • July 7, 2026

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