Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers - Takeaways - MDSpire

Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers

  • By

  • Yingying Wang

  • Qiyue Chao

  • Xiaoyan Lu

  • Yichi Zhou

  • Zhiwen Xie

  • Shiyun Zhang

  • Fei Xu

  • Sikao Wu

  • Lvzhong Hu

  • Bo Ding

  • Xinyi Zhang

  • Tianmin Xu

  • Guantai Ni

  • Jing Liang

  • Jinhua Zhou

  • Yang Shen

  • Bo Yang

  • Shengtao Zhou

  • Xiaojun Chen

  • Tingyan Shi

  • Chunyan Lan

  • Tao Zhu

  • Ying Zhou

  • November 7, 2025

  • 0 min

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  • 1

    Brain metastases occur in 2.5%-6.0% of ovarian cancer patients, with a 5-year overall survival rate of only 29.2%.

  • 2

    The study analyzed 129 ovarian cancer patients with brain metastases across 12 Chinese institutions from 2010 to 2022.

  • 3

    Independent predictors of poor prognosis include high serum CA-125 levels, multiple brain metastases, and headache attributed to brain metastases.

  • 4

    Patients diagnosed with brain metastases during second-line or later relapse showed better overall survival compared to those diagnosed earlier.

  • 5

    The study highlights the need for standardized treatment protocols for brain metastases in ovarian cancer to improve patient management.

Original Source(s)

Prognostic Indicators and Clinical Characteristics of Brain Metastases in Ovarian Cancer: A Retrospective Analysis of 129 Cases Across Multiple Centers

  • by Yingying Wang, Qiyue Chao, Xiaoyan Lu, Yichi Zhou, Zhiwen Xie, Shiyun Zhang, Fei Xu, Sikao Wu, Lvzhong Hu, Bo Ding, Xinyi Zhang, Tianmin Xu, Guantai Ni, Jing Liang, Jinhua Zhou, Yang Shen, Bo Yang, Shengtao Zhou, Xiaojun Chen, Tingyan Shi, Chunyan Lan, Tao Zhu, Ying Zhou

  • November 7, 2025

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