Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction - Takeaways - MDSpire

Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction

  • By

  • Quanlei Wang

  • Shun Ruan

  • Xiyin Ye

  • Haifeng Wang

  • Quli Zeng

  • Xiao Luo

  • Kai Guo

  • Ailing Zhang

  • Huixiang Huang

  • Gang Wu

  • Haibo Chen

  • Suhui Zeng

  • Tiansheng Xie

  • Wanhong Liang

  • Weihong Duan

  • Sangui Wang

  • June 8, 2026

  • 0 min

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  • 1

    Gallbladder cancer is a highly lethal malignancy, with mixed neuroendocrine-non-neuroendocrine neoplasms being particularly rare and aggressive.

  • 2

    A 78-year-old female was diagnosed with a mixed adenoma-large cell neuroendocrine carcinoma of the gallbladder, confirmed by pathology and immunohistochemistry.

  • 3

    The patient underwent extensive radical surgery, including partial hepatectomy and portal vein reconstruction, achieving negative surgical margins.

  • 4

    Postoperative pathology indicated multiple metastases, with immunohistochemistry showing high Ki-67 proliferation index and positivity for neuroendocrine markers.

  • 5

    This case highlights the importance of multidisciplinary collaboration in managing rare and complex gallbladder tumors.

Original Source(s)

Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction

  • by Quanlei Wang, Shun Ruan, Xiyin Ye, Haifeng Wang, Quli Zeng, Xiao Luo, Kai Guo, Ailing Zhang, Huixiang Huang, Gang Wu, Haibo Chen, Suhui Zeng, Tiansheng Xie, Wanhong Liang, Weihong Duan, Sangui Wang

  • June 8, 2026

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