Rare Skin Reaction Reported With Tirzepatide

A single case report described possible lichen planus pigmentosus inversus following tirzepatide initiation.

1

Tirzepatide use was associated with the onset of lichen planus pigmentosus inversus in a 46-year-old female patient.
2

The patient developed pruritic brown macules in the axillae and groin 6 to 7 months after starting tirzepatide for weight loss.
3

A shave biopsy confirmed the diagnosis, showing lichenoid interface dermatitis and supporting a drug-induced eruption pattern.
4

The patient's hyperpigmentation persisted despite treatment with topical tacrolimus, and she chose to continue tirzepatide therapy.
5

This case adds to limited reports of skin reactions from glucagon-like peptide-1 receptor agonists, with unclear mechanisms.

1