Randomized trial of thulium laser-assisted tumor bed coagulation versus conventional suture renorrhaphy in laparoscopic partial nephrectomy: impact on perioperative outcomes and fibrosis biomarker response - Takeaways - MDSpire

Randomized trial of thulium laser-assisted tumor bed coagulation versus conventional suture renorrhaphy in laparoscopic partial nephrectomy: impact on perioperative outcomes and fibrosis biomarker response

  • By

  • Ehab Atallah

  • Abdullah Dawoud

  • Abul-fotouh Ahmed

  • Abdelrahman Ebeid

  • Ahmed Soliman

  • Hassan Abdelazim

  • Awatef Soliman

  • Samar Abdelhamid

  • Aly M. Abdel-karim

  • December 17, 2025

  • 0 min

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  • 1

    Thulium laser-assisted laparoscopic partial nephrectomy (LLPN) aims to reduce ischemia and parenchymal injury compared to conventional suture renorrhaphy (CLPN).

  • 2

    The study is a randomized trial comparing perioperative outcomes and fibrosis biomarker responses between LLPN and CLPN in patients with small renal masses.

  • 3

    Primary endpoints include warm ischemia time and changes in urinary fibrosis biomarkers TGF-β1 and MCP-1, indicating fibrogenic activity.

  • 4

    Secondary endpoints assess intraoperative blood loss, operative time, renal function preservation, and complications graded by the Clavien–Dindo classification.

  • 5

    The trial is conducted at two tertiary care centers, enrolling patients with clinical T1 renal masses and excluding those with significant comorbidities.

Original Source(s)

Randomized trial of thulium laser-assisted tumor bed coagulation versus conventional suture renorrhaphy in laparoscopic partial nephrectomy: impact on perioperative outcomes and fibrosis biomarker response

  • by Ehab Atallah, Abdullah Dawoud, Abul-fotouh Ahmed, Abdelrahman Ebeid, Ahmed Soliman, Hassan Abdelazim, Awatef Soliman, Samar Abdelhamid, Aly M. Abdel-karim

  • December 17, 2025

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