Mass Spec Roundup: Hidden Signals and Sharper Reads

From hidden brain lipids to small-volume gas samples, mass spectrometry separates what overlap, scarcity, and similarity can obscure

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Targeted nano-DESI tandem mass spectrometry imaging effectively separates low-abundance plasmalogens from more abundant lipids in mouse brain tissue.
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A workflow developed by Julia Laskin's group resolved 38 plasmalogen species and revealed distinct distributions across various brain regions.
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A new N-terminal tagging method improved de novo sequencing of short peptides, enabling accurate characterization of peptides with four to ten amino acids.
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A preclinical fentanyl vaccine using a chemically distinct scaffold generated broadly cross-reactive antibodies and preserved ventilation in challenged mice.
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The modified fentanyl vaccine demonstrated potential for recognizing the entire fentanyl class, suggesting a proactive approach against emerging synthetic drugs.

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