Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways - Takeaways - MDSpire

Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways

  • By

  • Jiale Chen

  • Qianqian Li

  • Bingqing Ji

  • Ke Zhang

  • Miao Ren

  • Anan Li

  • Hui Gong

  • Jian Wang

  • Gang Cao

  • Qingming Luo

  • Xiangning Li

  • February 12, 2025

  • 0 min

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  • 1

    The study constructed a single-nucleus transcriptomic atlas of the basal forebrain across various developmental stages and ages.

  • 2

    Distinct molecular regulatory patterns and age-related pathways were identified, highlighting changes in cholinergic neurons during ageing.

  • 3

    Four potential regulatory networks linked to cholesterol metabolism, DNA damage repair, and death receptor signaling were discovered in 5xFAD mice.

  • 4

    The cholinergic subtype CN-2 showed increased activity of regulons associated with Srebf2 and Zmiz1, affecting key hub genes.

  • 5

    This research provides insights into the molecular mechanisms of ageing and neurodegeneration, aiding future therapeutic interventions.

Original Source(s)

Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways

  • by Jiale Chen, Qianqian Li, Bingqing Ji, Ke Zhang, Miao Ren, Anan Li, Hui Gong, Jian Wang, Gang Cao, Qingming Luo, Xiangning Li

  • February 12, 2025

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