Integrative multi-omics identifies MSR1 as a programmed cell death and extracellular matrix hub gene in osteoarthritis with hesperidin targeting potential - Takeaways - MDSpire

Integrative multi-omics identifies MSR1 as a programmed cell death and extracellular matrix hub gene in osteoarthritis with hesperidin targeting potential

  • By

  • Bao, Jinquan

  • Wu, Lingling

  • Zhao, Wenqiang

  • Li, Bo

  • Li, Zilong

  • Bai, Zhigang

  • Ma, Penglei

  • Gao, Bo

  • Qiao, Chenggang

  • March 30, 2026

  • 0 min

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  • 1

    Osteoarthritis (OA) involves complex molecular mechanisms, particularly the interplay between programmed cell death and extracellular matrix.

  • 2

    Multi-omics analysis identified MSR1 as a key gene associated with programmed cell death and extracellular matrix dynamics in OA.

  • 3

    MSR1 expression was significantly higher in OA samples compared to healthy samples, indicating its role in OA pathogenesis.

  • 4

    Hesperidin was identified as a high-affinity compound for MSR1, suggesting its potential as a therapeutic agent for OA.

  • 5

    The study provides a framework for understanding OA mechanisms and highlights the importance of MSR1 in immune modulation.

Original Source(s)

Integrative multi-omics identifies MSR1 as a programmed cell death and extracellular matrix hub gene in osteoarthritis with hesperidin targeting potential

  • by Bao, Jinquan , Wu, Lingling , Zhao, Wenqiang , Li, Bo , Li, Zilong , Bai, Zhigang , Ma, Penglei , Gao, Bo , Qiao, Chenggang

  • March 30, 2026

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