TOFA may drive weight loss without reducing food intake

The oral compound increased energy expenditure, reduced fat mass, and improved metabolic measures in male mouse models.

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TOFA reduced body weight and fat mass by an average of 18% in male mice without affecting food intake or lean mass.
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TOFA improved metabolic parameters, including fasting blood glucose, insulin levels, glucose tolerance, and insulin sensitivity.
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Increased energy expenditure of approximately 18% was observed in TOFA-treated mice, independent of increased physical activity.
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TOFA treatment resulted in lower liver triglycerides, cholesterol, and reduced hepatic steatosis and fibrosis in mice.
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Combination therapy with TOFA and incretin analogs led to greater weight loss and improved glucose control compared to monotherapy.

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