Primary diffuse leptomeningeal glioblastoma: a case report and literature review

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Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, with an incidence of 3 per 100,000 person years.
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Leptomeningeal disease (LMD) is a rare complication of GBM, with incidence rates potentially as high as 15-25% and survival estimates between 0.2 and 9.7 months.
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Primary leptomeningeal spread (LMS) of GBM is extremely rare, with most cases detected during recurrence within the first two years of disease.
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A case of a 72-year-old woman with GBM presenting solely as LMD without a primary parenchymal lesion was reported, highlighting its rarity.
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Pathology confirmed the diagnosis of glioblastoma, IDH-wildtype, CNS WHO grade 4, with a diffusely infiltrative growth pattern involving the leptomeninges.

Journal Of Neuro-Oncology

by Mark Willy L. Mondia, Rebekka E. Hooks, Georgios A. Maragkos, Vanessa L. Smith, Matthew R. McCord, Joseph H. Donahue, Eli S. Williams, M. Beatriz Lopes, David Schiff, Ashok R. Asthagiri
December 12, 2024

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