Central Retinal Artery Occlusion: An Uncommon Consequence of Acute Invasive Fungal Sinusitis Linked to Trichoderma - Takeaways - MDSpire

Central Retinal Artery Occlusion: An Uncommon Consequence of Acute Invasive Fungal Sinusitis Linked to Trichoderma

  • By

  • Li Farong

  • Li Xiaodong

  • Qin Xuewei

  • Liu Xin

  • November 25, 2025

  • 0 min

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  • 1

    Acute invasive fungal rhinosinusitis (AIFRS) is primarily caused by Aspergillus and Trichoderma, often in immunocompromised patients.

  • 2

    The case presented involves a 45-year-old male with AIFRS leading to secondary Central Retinal Artery Occlusion (CRAO), a rare complication.

  • 3

    Diagnosis of AIFRS was confirmed through nasal endoscopy and histopathological examination, while CRAO was diagnosed using Fundus Fluorescein Angiography and Optical Coherence Tomography.

  • 4

    AIFRS is highly lethal, with mortality rates ranging from 50% to 80%, and requires a multidisciplinary approach for effective diagnosis and treatment.

  • 5

    The patient's condition deteriorated despite treatment, leading to death due to sepsis and septic shock, highlighting the aggressive nature of AIFRS.

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