Case Report: Individualized management of tuberous sclerosis complex-associated lymphangioleiomyomatosis - Takeaways - MDSpire

Case Report: Individualized management of tuberous sclerosis complex-associated lymphangioleiomyomatosis

  • By

  • Gang Wang

  • Li Yang

  • Shiqing Qian

  • Sheng Hu

  • June 4, 2026

  • 0 min

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  • 1

    Tuberous sclerosis complex-associated lymphangioleiomyomatosis (TSC-LAM) primarily affects women of reproductive age and leads to cystic lung destruction.

  • 2

    A 36-year-old female patient with TSC-LAM experienced recurrent pneumothoraces correlated with her menstrual cycle and had multiple systemic manifestations.

  • 3

    The patient was treated with sirolimus, which maintained disease stability and reduced renal angiomyolipoma volume without significant adverse effects.

  • 4

    Regular follow-up included pulmonary function tests, imaging, and genetic counseling for early detection and prevention of disease transmission.

  • 5

    This case highlights the importance of individualized treatment and systematic family screening in managing heritable conditions like TSC-LAM.

Original Source(s)

Case Report: Individualized management of tuberous sclerosis complex-associated lymphangioleiomyomatosis

  • by Gang Wang, Li Yang, Shiqing Qian, Sheng Hu

  • June 4, 2026

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