Failure to Update ClinicalTrials.gov Record for a Clinical Trial - Takeaways - MDSpire

Neglecting to Revise ClinicalTrials.gov Entry for a Research Study

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1

Concerns about the trial's findings arose after publication due to social media and personal communications.
2

The study by Li et al. was published in JAMA Psychiatry on March 11, 2026, and registered on ClinicalTrials.gov in April 2018.
3

Substantial revisions to the trial record occurred in March 2025, altering primary outcomes and inclusion/exclusion criteria.
4

The authors published a revised protocol in a peer-reviewed journal in 2021, which was referenced in the JAMA Psychiatry article.
5

The central issue was the ClinicalTrials.gov record not being updated in real time, leading to misconceptions about protocol alterations.