Case Report: Successful treatment of refractory generalized pustular psoriasis with xeligekimab: a report of two cases - Takeaways - MDSpire

Case Report: Successful treatment of refractory generalized pustular psoriasis with xeligekimab: a report of two cases

  • By

  • Xiao Zang

  • Xiaoxuan Shi

  • Huijie Li

  • Na Wang

  • Qing Yang

  • June 12, 2026

  • 0 min

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  • 1

    Generalized pustular psoriasis (GPP) is a severe skin disorder with inadequate response to traditional therapies.

  • 2

    Xeligekimab, an anti-IL-17A monoclonal antibody, shows promise in treating refractory GPP.

  • 3

    Two patients with long-standing GPP experienced rapid improvement after a single dose of xeligekimab.

  • 4

    One patient maintained remission for three months following just one injection of xeligekimab.

  • 5

    This case study provides initial evidence for xeligekimab as an effective treatment option for GPP.

Original Source(s)

Case Report: Successful treatment of refractory generalized pustular psoriasis with xeligekimab: a report of two cases

  • by Xiao Zang, Xiaoxuan Shi, Huijie Li, Na Wang, Qing Yang

  • June 12, 2026

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