Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial

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Intravenous lidocaine significantly reduced postoperative pain scores in patients undergoing modified radical mastectomy compared to control groups.
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Lidocaine infusion lowered inflammatory markers IL-6, IL-1β, TNF-α, and NF-κB activity in patients, indicating an anti-inflammatory effect.
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The analgesic effect of lidocaine was consistent regardless of the maintenance anesthetic used, whether sevoflurane or propofol.
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No significant differences were found in anesthetic consumption, adverse events, or patient satisfaction among the four study groups.
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Further randomized controlled trials are needed to confirm the findings and assess long-term outcomes of lidocaine in postoperative pain management.

Frontiers In Medicine

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