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1
Macrophages are crucial in inflammation, tissue repair, and fibrosis, exhibiting dynamic changes in phenotype and function.
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2
Following injury, macrophages initially rely on glycolysis and the pentose phosphate pathway, transitioning to a pro-inflammatory phenotype.
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3
As the metabolic environment changes, macrophages shift towards an anti-inflammatory phenotype, essential for tissue repair and remodeling.
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4
Sustained activation of anti-inflammatory macrophages may lead to fibrosis, indicating the need for metabolic reprogramming as a therapeutic target.
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5
Research on macrophage plasticity and metabolic reprogramming can inform strategies for treating chronic wounds, fibrotic diseases, and inflammatory disorders.
