The role of lipid metabolism and creeping fat in disease assessment and prediction for Crohn’s disease

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Crohn's Disease (CD) is a chronic inflammatory bowel disease that can lead to significant disability and requires effective monitoring for better outcomes.
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Creeping fat (CF) is a unique pathological feature in CD, contributing to intestinal inflammation, fibrosis, and stricture formation.
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Dyslipidemia during the active phase of CD is closely linked to systemic inflammation severity and may reflect disease activity.
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Current imaging techniques allow for the assessment of CF, which can help predict surgical risks and postoperative recurrence in CD patients.
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Exploring lipid metabolism and CF roles in CD can enhance disease assessment accuracy and provide new targets for prognosis prediction.

Frontiers In Immunology

by Ying Lei, Runjie Shi, Zihong Cai, Yiqing Li, Xiaowei Qiu, Xiang Li, Shanping Wang, Yan Sun
May 25, 2026

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