Cytokine-induced chromatin accessibility in whole blood neutrophils links to sepsis transcriptional states - Takeaways - MDSpire

Cytokine-induced chromatin accessibility in whole blood neutrophils links to sepsis transcriptional states

  • By

  • Justin Cayford

  • Brandi Atteberry

  • Akanksha Singh-Taylor

  • Andrew Retter

  • Benjamin P. Berman

  • Theresa K. Kelly

  • June 10, 2026

  • 0 min

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  • 1

    Neutrophils form extracellular traps (NETs) to immobilize pathogens, but excessive NET release is linked to severe conditions like sepsis.

  • 2

    The study utilized ATAC-Seq to profile chromatin accessibility in neutrophils stimulated by natural inflammatory factors in whole blood.

  • 3

    Natural factors induced distinct chromatin accessibility programs in neutrophils, differing from those induced by PMA.

  • 4

    Chromatin accessibility changes correlated with transcriptional states associated with sepsis severity, highlighting regulatory mechanisms.

  • 5

    The findings provide a framework for understanding how cytokine-driven changes in neutrophils relate to inflammatory disease endotypes.

Original Source(s)

Cytokine-induced chromatin accessibility in whole blood neutrophils links to sepsis transcriptional states

  • by Justin Cayford, Brandi Atteberry, Akanksha Singh-Taylor, Andrew Retter, Benjamin P. Berman, Theresa K. Kelly

  • June 10, 2026

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