Serum CitH3 and TSLP as predictive biomarkers for impaired wound healing after bascom cleft lift surgery in pilonidal sinus disease: a nomogram-based risk model - Takeaways - MDSpire

Serum CitH3 and TSLP as predictive biomarkers for impaired wound healing after bascom cleft lift surgery in pilonidal sinus disease: a nomogram-based risk model

  • By

  • Junyue Huo

  • Binghui Hu

  • Xiufang Lu

  • Bo Zhang

  • Bingjie Wang

  • May 4, 2026

  • 0 min

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  • 1

    Serum CitH3 and TSLP levels are significant predictors of postoperative wound healing outcomes in patients undergoing Bascom cleft lift for pilonidal sinus disease.

  • 2

    The study categorized 181 patients into good-healing and poor-healing cohorts based on wound outcomes at 6 weeks post-surgery.

  • 3

    Poor-healing patients exhibited higher BMI, FBG, CRP, CitH3, and TSLP levels, and lower albumin compared to the good-healing group.

  • 4

    A nomogram developed from the study showed excellent predictive performance with AUC values of 0.958 and 0.970 in training and validation cohorts, respectively.

  • 5

    The findings suggest that CitH3 and TSLP could serve as biomarkers for assessing wound healing risks, warranting further validation in larger studies.

Original Source(s)

Serum CitH3 and TSLP as predictive biomarkers for impaired wound healing after bascom cleft lift surgery in pilonidal sinus disease: a nomogram-based risk model

  • by Junyue Huo, Binghui Hu, Xiufang Lu, Bo Zhang, Bingjie Wang

  • May 4, 2026

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